- Title
- Increased erythrocyte eicosapentaenoic acid and docosahexaenoic acid are associated with improved attention and behavior in children with adhd in a randomized controlled three-way crossover trial
- Creator
- Milte, Catherine M.; Parletta, Natalie; Buckley, Jonathan D.; Coates, Alison M.; Young, Ross M.; Howe, Peter R. C.
- Relation
- ARC.LP0776922
- Relation
- Journal of Attention Disorders Vol. 19, Issue 11, p. 954-964
- Publisher Link
- http://dx.doi.org/10.1177/1087054713510562
- Publisher
- Sage
- Resource Type
- journal article
- Date
- 2015
- Description
- Objective: To investigate effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on attention, literacy, and behavior in children with ADHD. Method: Ninety children were randomized to consume supplements high in EPA, DHA, or linoleic acid (control) for 4 months each in a crossover design. Erythrocyte fatty acids, attention, cognition, literacy, and Conners' Parent Rating Scales (CPRS) were measured at 0, 4, 8, 12 months. Results: Fifty-three children completed the treatment. Outcome measures showed no significant differences between the three treatments. However, in children with blood samples (n = 76-46), increased erythrocyte EPA + DHA was associated with improved spelling (r =.365, p <.001) and attention (r = -.540, p <.001) and reduced oppositional behavior (r = -.301, p <.003), hyperactivity (r = -.310, p <.001), cognitive problems (r = -.326, p <.001), Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) hyperactivity (r = -.270, p =.002) and DSM-IV inattention (r = -.343, p <.001). Conclusion: Increasing erythrocyte DHA and EPA via dietary supplementation may improve behavior, attention, and literacy in children with ADHD.
- Subject
- ADD/ADHD; behavior; cognition; fatty acid; nutrition
- Identifier
- http://hdl.handle.net/1959.13/1330891
- Identifier
- uon:26499
- Identifier
- ISSN:1087-0547
- Language
- eng
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